Clothes is the general word for the things that you wear such as shirts, dresses, trousers, etc.
Wear is used to describe the clothes that are suitable for a particular activity. You need to mention the activity:
(Clothes you wear to sleep in.)
- Evening wear
(Clothes you wear to go to a party.)
- Children’s wear
(Clothes children wear.)
(Clothes you wear to play sport.)
- There is a pile of dirty clothes on the floor.
- I’m going to put on some clean clothes.
- I didn’t bring any evening wear.
- I need to buy some new nightwear.